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Journal article

Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.

Abstract:

BACKGROUND: Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells to form gap junctions and thereby provide a pathway for regulated intercellular communication. We have examined the role of connexins in platelets, blood cells that circulate in isolation but on tissue injury adhere to each other and the vessel wall to prevent blood l...

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Publication status:
Published

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Authors


Vaiyapuri, S More by this author
Sasikumar, P More by this author
Moraes, LA More by this author
Munger, SJ More by this author
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Journal:
Circulation
Volume:
125
Issue:
20
Pages:
2479-2491
Publication date:
2012-05-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:7ffc687a-e0e5-4bf7-9c38-fa43747c52f5
Source identifiers:
335275
Local pid:
pubs:335275

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