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In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

Abstract:

Recent drug trials in Laos have shown high levels of Plasmodium falciparum resistance to chloroquine, but there are no published data on in vitro antimalarial drug susceptibility. We used the double-site enzyme-linked pLDH immunodetection (DELI) assay to estimate the in vitro antimalarial drug susceptibility of 108 fresh P. falciparum isolates from southern Laos. The geometric mean (95% confidence interval) 50% inhibitory concentration values (nmol/L) were 152.4 (123.8-187.6) for chloroquine,...

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Publication status:
Published

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Journal:
The American journal of tropical medicine and hygiene
Volume:
76
Issue:
2
Pages:
245-250
Publication date:
2007-02-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:7ffac41a-82aa-4ad1-a252-044bdde2770b
Source identifiers:
14987
Local pid:
pubs:14987

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