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ERK2 signalling from internalised epidermal growth factor receptor in broken A431 cells.

Abstract:

Activation of extracellular signal-regulated kinase 2 (ERK2) signalling from epidermal growth factor receptors (EGFRs) is widely assumed to originate in the plasma membrane. Using an in vitro assay, we investigated whether EGF/EGFR complexes internalised by endocytosis in A431 cells can initiate signalling in the ERK2 pathway. At 0 degrees C, binding of EGF induced tyrosine phosphorlyation of EGFR and, when the cells were subsequently broken by scraping and warmed in the presence of exogenous...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Cellular signalling
Volume:
10
Issue:
5
Pages:
339-348
Publication date:
1998-05-05
DOI:
EISSN:
1873-3913
ISSN:
0898-6568
URN:
uuid:7ff8a39e-5c63-4a4f-8dcc-00a44b3d84e4
Source identifiers:
111096
Local pid:
pubs:111096

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