Journal article icon

Journal article

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant

Abstract:

A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this function in human cells is presently unknown, recent studies led to the identification of the XPG-family endonuclease GEN1 that promotes Holliday junction resolution in vitro, suggesting that it may perform a related function in vivo. Here, we show that ectopic expression of GEN1 in fission yeast mus81Δ strains result in...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1093/nar/gkp1179

Authors


More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
Role:
Author
More by this author
Institution:
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
Role:
Author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
38
Issue:
6
Pages:
1866-1873
Publication date:
2010-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:7ff5d597-4394-4c83-85d6-f98761b93b6e
Local pid:
ora:5201
Language:
English
Subjects:

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP