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The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant

Abstract:

A key step in meiotic recombination involves the nucleolytic resolution of Holliday junctions to generate crossovers. Although the enzyme that performs this function in human cells is presently unknown, recent studies led to the identification of the XPG-family endonuclease GEN1 that promotes Holliday junction resolution in vitro, suggesting that it may perform a related function in vivo. Here, we show that ectopic expression of GEN1 in fission yeast mus81Δ strains result in...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkp1179

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Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
More by this author
Institution:
Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Biochemistry
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
38
Issue:
6
Pages:
1866-1873
Publication date:
2010
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:7ff5d597-4394-4c83-85d6-f98761b93b6e
Local pid:
ora:5201
Language:
English
Subjects:

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