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Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.

Abstract:

The bacterial channel KirBac1.1 provides a structural homolog of mammalian inward rectifier potassium (Kir) channels. The conformational dynamics of the selectivity filter of Kir channels are of some interest in the context of possible permeation and gating mechanisms for this channel. Molecular dynamics simulations of KirBac have been performed on a 10-ns timescale, i.e., comparable to that of ion permeation. The results of five simulations (total simulation time 50 ns) based on three differ...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.104.039917

Authors


Grottesi, A More by this author
Sansom, MS More by this author
Journal:
Biophysical journal
Volume:
87
Issue:
1
Pages:
256-267
Publication date:
2004-07-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:7fdbb227-ba0f-49c6-b984-90c4fc3cdaf6
Source identifiers:
100588
Local pid:
pubs:100588

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