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Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus

Abstract:

Dengue virus is a major pathogen and severe infections can lead to life threatening dengue hemorrhagic fever (DHF). Dengue exists as four serotypes and DHF is often associated with secondary heterologous infections. Antibody dependent enhancement (ADE) may drive higher virus loads in these secondary infections, and is purported to result from antibodies that recognize dengue but fail to fully neutralize. We have characterized two antibodies, 2C8 and 3H5, which bind to the envelope protein. 3H...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41590-018-0227-7

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Puttikhunt, C More by this author
Kasinrerk, W More by this author
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Funding agency for:
Renner, M
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Funding agency for:
Flanagan, A
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Funding agency for:
Screaton, G
Newton-Medical Research Counci More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Immunology Journal website
Volume:
19
Pages:
1248–1256
Publication date:
2018-10-15
Acceptance date:
2018-08-21
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pubs id:
pubs:910956
URN:
uri:7fdb4275-94fb-43a4-965d-cf125c84ba85
UUID:
uuid:7fdb4275-94fb-43a4-965d-cf125c84ba85
Local pid:
pubs:910956

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