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Antipsychotic drug effects in a model of schizophrenic attentional disorder: a randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people.

Abstract:
We studied the effects of haloperidol (0.5 mg, intravenously) on latent inhibition in an auditory paradigm and two visual paradigms in healthy subjects. Haloperidol increased latent inhibition in one visual paradigm and tended to increase latent inhibition in an auditory task, compared to saline-injected controls. These results indicate that haloperidol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent inhibition.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Biological psychiatry
Volume:
40
Issue:
11
Pages:
1135-1143
Publication date:
1996-12-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:7fb2d17a-ec39-472f-9f26-9008347874dd
Source identifiers:
8981
Local pid:
pubs:8981

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