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Journal article

Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities

Abstract:

Aims

To identify key structural and electrophysiological features explaining distinct electrocardiogram (ECG) phenotypes in hypertrophic cardiomyopathy (HCM).

Methods and results

Human heart–torso anatomical models were constructed from cardiac magnetic resonance (CMR) images of HCM patients, representative of ECG phenotypes identified previously. High performance computing simulations using bidomain models were conducted to dissect ke...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/europace/euy226

Authors


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Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM Cardiovascular Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Maths, Physical & Life Sciences
Department:
Engineering Science
Role:
Author
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Funding agency for:
Bueno Orovio, A
Grant:
Intermediate Basic Science Research Fellowship: FS/17/22/32644
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Funding agency for:
Zacur, E
Grant:
Marie Sklodowska-Curie Individual Fellowship: 655020-DTI4micro-MSCA-IF-EF-ST
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Funding agency for:
Zacur, E
Grant:
Marie Sklodowska-Curie Individual Fellowship: 655020-DTI4micro-MSCA-IF-EF-ST
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Funding agency for:
Ariga, R
Grant:
Clinical Research Training Fellowship: FS/12/32/29559
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Publisher:
Oxford University Press Publisher's website
Journal:
EP-Europace Journal website
Volume:
20
Issue:
S3
Pages:
iii102–iii112
Publication date:
2018-11-23
Acceptance date:
2018-09-27
DOI:
EISSN:
1532-2092
ISSN:
1099-5129
Source identifiers:
920423
Keywords:
Pubs id:
pubs:920423
UUID:
uuid:7faf248e-3466-4637-8622-5a8cfc624a9a
Local pid:
pubs:920423
Deposit date:
2018-09-19

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