Journal article
Electrocardiogram phenotypes in hypertrophic cardiomyopathy caused by distinct mechanisms: apico-basal repolarization gradients vs. Purkinje-myocardial coupling abnormalities
- Abstract:
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Aims
To identify key structural and electrophysiological features explaining distinct electrocardiogram (ECG) phenotypes in hypertrophic cardiomyopathy (HCM).
Methods and results
Human heart–torso anatomical models were constructed from cardiac magnetic resonance (CMR) images of HCM patients, representative of ECG phenotypes identified previously. High performance computing simulations using bidomain models were conducted to dissect ke...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1093/europace/euy226
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Authors
Funding
+ British Heart Foundation
More from this funder
Funding agency for:
Bueno Orovio, A
Grant:
Intermediate Basic Science Research Fellowship: FS/17/22/32644
+ British Heart Foundation
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Funding agency for:
Zacur, E
Grant:
Marie Sklodowska-Curie Individual Fellowship: 655020-DTI4micro-MSCA-IF-EF-ST
+ European Comission
More from this funder
Funding agency for:
Zacur, E
Grant:
Marie Sklodowska-Curie Individual Fellowship: 655020-DTI4micro-MSCA-IF-EF-ST
+ British Heart Foundation
More from this funder
Funding agency for:
Ariga, R
Grant:
Clinical Research Training Fellowship: FS/12/32/29559
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- EP-Europace Journal website
- Volume:
- 20
- Issue:
- S3
- Pages:
- iii102–iii112
- Publication date:
- 2018-11-23
- Acceptance date:
- 2018-09-27
- DOI:
- EISSN:
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1532-2092
- ISSN:
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1099-5129
- Source identifiers:
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920423
Item Description
- Keywords:
- Pubs id:
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pubs:920423
- UUID:
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uuid:7faf248e-3466-4637-8622-5a8cfc624a9a
- Local pid:
- pubs:920423
- Deposit date:
- 2018-09-19
Terms of use
- Copyright holder:
- Lyon et al
- Copyright date:
- 2018
- Notes:
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© The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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