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Plasmodium vivax susceptibility to ferroquine.

Abstract:
The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria.
Publication status:
Published

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Publisher copy:
10.1128/aac.01572-09

Authors


Leimanis, ML More by this author
Sriprawat, K More by this author
Kaewpongsri, S More by this author
Suwanarusk, R More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
54
Issue:
5
Pages:
2228-2230
Publication date:
2010-05-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:7fa73f04-4b3f-4299-8ec1-69368b7e3828
Source identifiers:
51928
Local pid:
pubs:51928

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