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The role of axonal pathology in MS disability

Abstract:

It is well recognized that in end-stage multiple sclerosis (MS) pathology there is axon loss. Since the axons of central nervous system fibre tracts regenerate very poorly (if at all), it is axon loss that is likely to be responsible for the permanent clinical deficits of MS. Thus, the key question is not whether there is axon degeneration in MS, but when it occurs during the course of the disease. If it develops early in the disease, and is not just a consequence of long-standing demyelinati...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
International MS Journal
Volume:
6
Issue:
1
Pages:
6-13
Publication date:
1999-01-01
ISSN:
1352-8963
URN:
uuid:7f98bf78-00f6-4e98-a9da-042f5f43e8cd
Source identifiers:
383112
Local pid:
pubs:383112
Language:
English

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