Journal article
Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group.
- Abstract:
-
BACKGROUND: There is now increasing evidence that a constitutive expression of cyclooxygenase (COX)-2 plays a role in the development and progression of malignant epithelial tumors. Expression of COX-2 is seen in 93% of melanomas, as determined by immunohistochemistry. Temozolomide (TMZ) has demonstrated activity against melanoma and has been investigated as single agent or in combination. We designed a phase II study to assess the efficacy and toxicity of the combination of TMZ and celecoxib...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/annonc/mdl311
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Bibliographic Details
- Journal:
- Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
- Volume:
- 17
- Issue:
- 12
- Pages:
- 1835-1841
- Publication date:
- 2006-12-05
- DOI:
- EISSN:
-
1569-8041
- ISSN:
-
0923-7534
- URN:
-
uuid:7f974fd2-32e0-4148-adfa-205faef6cb3a
- Source identifiers:
-
119685
- Local pid:
- pubs:119685
Item Description
Terms of use
- Copyright date:
- 2006
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