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Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group.

Abstract:

BACKGROUND: There is now increasing evidence that a constitutive expression of cyclooxygenase (COX)-2 plays a role in the development and progression of malignant epithelial tumors. Expression of COX-2 is seen in 93% of melanomas, as determined by immunohistochemistry. Temozolomide (TMZ) has demonstrated activity against melanoma and has been investigated as single agent or in combination. We designed a phase II study to assess the efficacy and toxicity of the combination of TMZ and celecoxib...

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Publication status:
Published

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Publisher copy:
10.1093/annonc/mdl311

Authors


Polyzos, A More by this author
Stavrinidis, I More by this author
Frangia, K More by this author
Tsoutsos, D More by this author
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Journal:
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Volume:
17
Issue:
12
Pages:
1835-1841
Publication date:
2006-12-05
DOI:
EISSN:
1569-8041
ISSN:
0923-7534
URN:
uuid:7f974fd2-32e0-4148-adfa-205faef6cb3a
Source identifiers:
119685
Local pid:
pubs:119685

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