Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial.

Journal article

BACKGROUND: Moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy might improve survival and neurological outcomes at up to 18 months of age, although complete neurological assessment at this age is difficult. To ascertain more precisely the effect of therapeutic hypothermia on neonatal cerebral injury, we assessed cerebral lesions on MRI scans of infants who participated in the Total Body Hypothermia for Neonatal Encephalopathy (TOBY) trial. METHODS: In the TOBY trial hypoxi...

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Authors: Rutherford, M; Ramenghi, L; Edwards, A; Brocklehurst, P; Halliday, H

• Publication status: Published
• Journal: Lancet. Neurology
• Volume: 9
• Issue: 1
• Pages: 39-45
• Publication date: 2010-01-01
• DOI: 10.1016/s1474-4422(09)70295-9
• EISSN: 1474-4465
• ISSN: 1474-4422
• Language: English
• Keywords: Odds Ratio; Treatment Outcome; Hypothermia, Induced; Infant, Newborn; Hypoxia-Ischemia, Brain; Prognosis; Brain; Neuromuscular Diseases; Sensitivity and Specificity; Age Factors; Female; Electroencephalography; Male; Logistic Models; Severity of Illness Index; Humans; Magnetic Resonance Imaging