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Detection of a point mutation associated with high-level isoniazid resistance in Mycobacterium tuberculosis by using real-time PCR technology with 3'-minor groove binder-DNA probes.

Abstract:

Tuberculosis remains one of the leading infectious causes of death worldwide. The emergence of drug-resistant strains of Mycobacterium tuberculosis is a serious public health threat. Resistance to isoniazid (INH) is the most prevalent form of resistance in M. tuberculosis and is mainly caused by mutations in the catalase peroxidase gene (katG). Among high-level INH-resistant isolates (MIC > or = 2), 89% are associated with a mutation at codon 315 of katG. There is a need to develop rapid d...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Journal:
Journal of clinical microbiology
Volume:
41
Issue:
10
Pages:
4630-4635
Publication date:
2003-10-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:7f78f26c-9518-4206-b395-eb22bbf492b0
Source identifiers:
113026
Local pid:
pubs:113026

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