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A monoclonal antibody against human complement component C3: the production of C3 by human cells in vitro.

Abstract:

A monoclonal antibody (WM1) against the third component of human complement (C3) was produced by fusing P3-X63-Ag8 mouse myeloma cells with spleen cells from BALB/c mice immunized with purified C3. The specificity of WM1 antibody against C3 was established by its capacity to inhibit a standard C3 hemolytic assay and to immunoprecipitate C3 from human serum in the presence of S. aureus bacteria. Indirect binding assays indicate that the antibody is directed the C3c portion of C3. The immunopre...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830110215

Authors


Whitehead, AS More by this author
Bodmer, WF More by this author
Journal:
European journal of immunology
Volume:
11
Issue:
2
Pages:
140-146
Publication date:
1981-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:7f776027-517f-489c-9b58-afb7ca6c2f90
Source identifiers:
487552
Local pid:
pubs:487552

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