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T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.

Abstract:

Two different bispecific hybrid antibodies were generated by cell fusion of pairs of existing hybrid-myeloma cell lines. Both hybrid antibodies had similar specificity for human CD3 and mouse Thy-1 but differed in the isotypes of the immunoglobulin heavy chains. Hybrid HA2b/2b was a hybrid between a rat IgG2b (CD3) and a rat IgG2b anti-Thy-1, whereas HA2b/2c was a hybrid between the same rat IgG2b (CD3) and a rat IgG2c anti-Thy-1. Both hybrid antibodies were found to be very potent in inducin...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of the National Cancer Institute
Volume:
79
Issue:
6
Pages:
1393-1401
Publication date:
1987-12-05
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:7f660bee-ec5c-4a24-bbcf-5a0f42f06529
Source identifiers:
18249
Local pid:
pubs:18249

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