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The partial reduction of electron-deficient pyrroles: procedures describing both Birch (Li/NH3) and ammonia-free (Li/DBB) conditions.

Abstract:

The partial reduction of electron-deficient pyrroles using either Birch (Li/NH(3)) or ammonia-free (Li/di-tert-butyl biphenyl) conditions allows formation of pyrroline compounds in good yield and, when combined with a reductive alkylation or similar approach, leads to highly functionalized, synthetically useful compounds. This methodology has been proven in the syntheses of several complex natural products, all of which show interesting biological activity. This protocol describes in detail t...

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Publication status:
Published

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Publisher copy:
10.1038/nprot.2007.245

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Nature protocols
Volume:
2
Issue:
8
Pages:
1888-1895
Publication date:
2007-01-01
DOI:
EISSN:
1750-2799
ISSN:
1754-2189
URN:
uuid:7f63b26c-2147-4086-9de9-9f15f415ab8a
Source identifiers:
33943
Local pid:
pubs:33943

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