Journal article

The partial reduction of electron-deficient pyrroles: procedures describing both Birch (Li/NH3) and ammonia-free (Li/DBB) conditions.

Abstract:: The partial reduction of electron-deficient pyrroles using either Birch (Li/NH(3)) or ammonia-free (Li/di-tert-butyl biphenyl) conditions allows formation of pyrroline compounds in good yield and, when combined with a reductive alkylation or similar approach, leads to highly functionalized, synthetically useful compounds. This methodology has been proven in the syntheses of several complex natural products, all of which show interesting biological activity. This protocol describes in detail t...
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Publication status:: Published

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APA Style

Donohoe, T., & Thomas, R. (2007). The partial reduction of electron-deficient pyrroles: procedures describing both Birch (Li/NH3) and ammonia-free (Li/DBB) conditions. Nature Protocols, 2(8), 1888–1895.

MLA Style

Donohoe, T., and R. Thomas. “The Partial Reduction of Electron-Deficient Pyrroles: Procedures Describing Both Birch (Li/NH3) and Ammonia-Free (Li/DBB) Conditions.” Nature Protocols, vol. 2, no. 8, 2007, pp. 1888–95.

Chicago Style

Donohoe, T, and R Thomas. 2007. “The Partial Reduction of Electron-Deficient Pyrroles: Procedures Describing Both Birch (Li/NH3) and Ammonia-Free (Li/DBB) Conditions.” Nature Protocols 2 (8): 1888–95.
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Publisher copy:: 10.1038/nprot.2007.245

Authors

+ Donohoe, T More by this author

Institution:

University of Oxford

Division:

MPLS

Department:

Chemistry

Sub department:

Organic Chemistry

Role:

Author

+ Thomas, R More by this author

Role:

Author

Bibliographic Details

Journal:: Nature protocols More from this journal
Volume:: 2
Issue:: 8
Pages:: 1888-1895
Publication date:: 2007-01-01
DOI:: 10.1038/nprot.2007.245
EISSN:: 1750-2799
ISSN:: 1754-2189

Item Description

Language:: English
Keywords:: Biphenyl Compounds

Biochemistry

Pyrroles

Lithium

Oxidation-Reduction

Electrons

Ammonia
Pubs id:: pubs:33943
UUID:: uuid:7f63b26c-2147-4086-9de9-9f15f415ab8a
Local pid:: pubs:33943
Source identifiers:: 33943
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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