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Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?

Abstract:

A 77G allele of the gene encoding CD45, also known as the protein tyrosine phosphatase receptor-type C gene (PTPRC), has been associated with multiple sclerosis (MS). Here we determine allele frequencies in large numbers of MS patients, primary immunodeficiencies linked to major histocompatibility complex (MHC) locus and over 1,000 controls to assess whether aberrant splicing of PTPRC caused by the 77C-->G polymorphism results in increased susceptibility to these diseases. Our results show...

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Publication status:
Published

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Publisher copy:
10.1038/ng723

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Nature genetics
Volume:
29
Issue:
1
Pages:
22-23
Publication date:
2001-09-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:7f626cbc-b2b0-46a6-98f3-d58f5b3e89e3
Source identifiers:
31941
Local pid:
pubs:31941

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