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Measurement of the noncomplexed free fraction of tissue inhibitor of metalloproteinases 1 in plasma by immunoassay.

Abstract:

BACKGROUND: We previously found differences in total concentrations of tissue inhibitor of metalloproteinases 1 (TIMP-1) in plasma from donors and cancer patients. Because TIMP-1 can exist in more than one molecular form, a new immunoassay to specifically detect free TIMP-1 was developed and concentrations were determined in plasma from healthy donors and colorectal cancer (CRC) patients. METHODS: We established and validated an immunoassay for the specific measurement of free TIMP-1 that us...

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
Clinical chemistry
Volume:
48
Issue:
8
Pages:
1305-1313
Publication date:
2002-08-05
EISSN:
1530-8561
ISSN:
0009-9147
URN:
uuid:7f5c3d79-9112-421c-9fbf-77f9994fa5f0
Source identifiers:
366027
Local pid:
pubs:366027

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