Measurement of the noncomplexed free fraction of tissue inhibitor of metalloproteinases 1 in plasma by immunoassay.

Holten-Andersen, MN; Christensen, IJ; Nielsen, HJ; Lilja, H; Murphy, G; Jensen, V; Brünner, N; Piironen, T

Abstract:

BACKGROUND: We previously found differences in total concentrations of tissue inhibitor of metalloproteinases 1 (TIMP-1) in plasma from donors and cancer patients. Because TIMP-1 can exist in more than one molecular form, a new immunoassay to specifically detect free TIMP-1 was developed and concentrations were determined in plasma from healthy donors and colorectal cancer (CRC) patients. METHODS: We established and validated an immunoassay for the specific measurement of free TIMP-1 that us...

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APA Style

Holten-Andersen, M. N., Christensen, I. J., Nielsen, H. J., Lilja, H., Murphy, G., Jensen, V., Brünner, N., & Piironen, T. (2002). Measurement of the noncomplexed free fraction of tissue inhibitor of metalloproteinases 1 in plasma by immunoassay. Clinical Chemistry, 48(8), 1305–1313.

MLA Style

Holten-Andersen, M. N., et al. “Measurement of the Noncomplexed Free Fraction of Tissue Inhibitor of Metalloproteinases 1 in Plasma by Immunoassay.” Clinical Chemistry, vol. 48, no. 8, 2002, pp. 1305–13.

Chicago Style

Holten-Andersen, MN, IJ Christensen, HJ Nielsen, H Lilja, G Murphy, V Jensen, N Brünner, and T Piironen. 2002. “Measurement of the Noncomplexed Free Fraction of Tissue Inhibitor of Metalloproteinases 1 in Plasma by Immunoassay.” Clinical Chemistry 48 (8): 1305–13.
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