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Nucleoporin 54 contributes to Homologous recombination repair and post-replicative DNA integrity

Abstract:

The nuclear pore complex (NPC) machinery is emerging as an important determinant in the maintenance of genome integrity and sensitivity to DNA double-strand break (DSB)-inducing agents, such as ionising radiation (IR). In this study, using a high-throughput siRNA screen, we identified the central channel NPC protein Nup54, and concomitantly its molecular partners Nup62 and Nup58, as novel factors implicated in radiosensitivity. Nup54 depletion caused an increase in cell death by mitotic catas...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gky569

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Funding agency for:
McKenna, WG
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Funding agency for:
Higgins, G
Cancer Research UK More from this funder
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
2018
Issue:
1
Publication date:
2018-07-09
Acceptance date:
2018-06-14
DOI:
ISSN:
0305-1048
Pubs id:
pubs:858127
URN:
uri:7f5b309a-fd92-47a5-acac-4218dac45a1c
UUID:
uuid:7f5b309a-fd92-47a5-acac-4218dac45a1c
Local pid:
pubs:858127

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