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Thesis

Isoenzyme specific PFK-2/FBPas-2 inhibition as an anti-cancer strategy

Abstract:

High aerobic glycolytic capacity is correlated with poor prognosis and increased tumour aggressiveness. 6Phosphofructo-1-kinase catalyses the first irreversible step of glycolysis, and is activated by fructose-2,6-bisphosphate, a product of the kinase activity of four bifunctional isoenzymes, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFK-2/FBPase-2:PFKFB1-4). These are potential anti-tumour targets, but their individual and collective role requires further investigation.

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Institution:
University of Oxford
Research group:
Prof. Adrian Harris, Dr Angela Russell
Oxford college:
Jesus College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Jonathan Glyn Williams
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:7f47d9bb-7a9d-4dbc-92fa-57d2654640d1
Local pid:
ora:12306

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