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Hedging against antiviral resistance during the next influenza pandemic using small stockpiles of an alternative chemotherapy

Abstract:

The effectiveness of single-drug antiviral interventions to reduce morbidity and mortality during the next influenza pandemic will be substantially weakened if transmissible strains emerge which are resistant to the stockpiled antiviral drugs. We developed a mathematical model to test the hypothesis that a small stockpile of a secondary antiviral drug could be used to mitigate the adverse consequences of the emergence of resistant strains.We used a multistrain stochastic transmission model of...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1000085

Authors


Lipsitch, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
PLoS Medicine Journal website
Volume:
6
Issue:
5
Pages:
Article: e1000085
Publication date:
2009-05-05
DOI:
EISSN:
1549-1676
URN:
uuid:7f42aa56-c891-40f2-b464-b2fd0adfcf88
Source identifiers:
223874
Local pid:
pubs:223874

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