Catalytic enantioselective desymmetrisation as a tool for the synthesis of hodgkinsine and hodgkinsine B.

Journal article

Two palladium-catalysed amination protocols are deployed in the desymmetrisation of the complex dimeric alkaloid meso-chimonanthine. The power of these transformations is showcased in an efficient formal and total synthesis of the natural products hodgkinsine and hodgkinsine B, respectively.

Authors: Snell, R; Durbin, M; Woodward, R; Willis, M; Snell, R

• Publication status: Published
• Peer review status: Peer reviewed
• Journal: Chemistry - A European Journal
• Volume: 18
• Issue: 52
• Pages: 10
• Publication date: 2012-01-01
• DOI: 10.1002/chem.201203150
• EISSN: 1521-3765
• ISSN: 1521-3765 and 0947-6539
• Language: English
• Keywords: Molecular Structure; Chemistry Techniques, Synthetic; Palladium; Pyrroles; Catalysis; Indoles; Stereoisomerism; Amination
• Subjects: total synthesis; Chemistry and allied sciences; desymmetrization; natural products; heterocycles; alkaloids