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The role of the major histocompatibility complex in in vitro antibody responses; MHC restriction in responses involving linked recognition of antigenic determinants is not solely consequent to T cell-accessory cell restrictions.

Abstract:

Major histocompatibility complex (MHC) restrictions in the secondary antibody response in vitro to the soluble protein antigen trinitrophenyl keyhole limpet haemocyanin (TNP-KLH) were investigated. Experimental conditions were employed which ensured that co-operation between KLH-primed T cells and TNP-primed B cells was possible only through linked recognition of carrier and haptenic determinants. Under such conditions co-operation between T and B cells appears to be MHC-restricted. These exp...

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Publication status:
Published

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Authors


Sullivan, CP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Immunology
Volume:
51
Issue:
2
Pages:
351-360
Publication date:
1984-02-05
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:7f2c77ec-658d-4282-aa42-5f9955d6a41f
Source identifiers:
9651
Local pid:
pubs:9651

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