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Antidepressant controlled trial for negative symptoms in schizophrenia (ACTIONS): a double-blind, placebo-controlled, randomised clinical trial.

Abstract:

Background

Negative symptoms of schizophrenia represent deficiencies in emotional responsiveness, motivation, socialisation, speech and movement. When persistent, they are held to account for much of the poor functional outcomes associated with schizophrenia. There are currently no approved pharmacological treatments. While the available evidence suggests that a combination of antipsychotic and antidepressant medication may be effective in treating negative symptoms, it is too li...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3310/hta20290

Authors


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Department:
Oxford, MSD, Nuffield Department of Population Health, Population Health
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
National Institute for Health Research Publisher's website
Journal:
Health Technology Assessment Journal website
Volume:
20
Issue:
29
Pages:
1-46
Publication date:
2016-04-05
Acceptance date:
2015-12-05
DOI:
ISSN:
1366-5278 and 2046-4924
Pubs id:
pubs:617079
URN:
uri:7f27c12f-a9cf-43dd-8626-23e1711fa97d
UUID:
uuid:7f27c12f-a9cf-43dd-8626-23e1711fa97d
Local pid:
pubs:617079

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