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The role of LATS1 in DNA damage signalling

Abstract:

Genomic DNA is constantly exposed to assaults, which if not dealt with, can lead to genomic instability and carcinogenesis. In response to stress including either Ionising Radiation (IR) or replication stress, ATM and ATR promote the activation of cell cycle checkpoints and initiate repair of DNA damage. Recent studies have revealed that ATM signalling can activate LATS1 via a cascade through RASSF1A and MST2. LATS1 is a tumour suppressor, which forms a barrier to carcinogenesis restrictin...

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Institution:
University of Oxford
Research group:
Eric O'Neill
Oxford college:
Balliol College
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Robert Latusek
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:7f21ecaf-20a6-45a9-8403-c8255955920e
Local pid:
ora:12079

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