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Hotspots of mutation and breakage in dog and human chromosomes.

Abstract:

Sequencing of the dog genome allows an investigation of the location-dependent evolutionary processes that occurred since the common ancestor of primates and carnivores, approximately 95 million years ago. We investigated variations in G+C nucleotide fraction and synonymous nucleotide substitution rates (Ks) across dog and human genomes. Our results show that dog genes located either in subtelomeric and pericentromeric regions, or in short synteny blocks, possess significantly elevated G+C fr...

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Publication status:
Published

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Publisher copy:
10.1101/gr.3896805

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Ponting, CP More by this author
Journal:
Genome research
Volume:
15
Issue:
12
Pages:
1787-1797
Publication date:
2005-12-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:7f12d73e-b3d6-42ca-bcfb-066112e794c2
Source identifiers:
237237
Local pid:
pubs:237237

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