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Journal article

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

Abstract:

The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by which the Hh signal is transmitted across the plasma membrane remains mysterious. This fundamental task in signalling is carried out by Smoothened (SMO), a human oncoprotein and validated cancer drug target that is a member of the G-protein couple...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ceb.2017.10.004

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Luchetti, G More by this author
Rohatgi, R More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
Oxford college:
St Cross College
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Grant:
European Union's Horizon 2020 Research and Innovation Programme Grant 647278
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Grant:
GM106078, GM105448 and GM118082
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Grant:
102890/Z/13/Z, 092970/Z/10/Z and 090532/Z/09/Z
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Cell Biology Journal website
Volume:
51
Pages:
81-88
Publication date:
2017-12-18
Acceptance date:
2017-12-18
DOI:
ISSN:
0955-0674
Pubs id:
pubs:821120
URN:
uri:7f122f45-3802-4d51-ac79-cd1836c9e99b
UUID:
uuid:7f122f45-3802-4d51-ac79-cd1836c9e99b
Local pid:
pubs:821120

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