The effect of hydration and matrix composition on solute diffusion in rabbit sclera.

Journal article

There is increasing interest in the possibility for drug delivery into the vitreous humor across the conjunctiva and sclera as an alternative route to the conjunctiva-cornea pathway. As a preliminary to human studies we have investigated the influence of scleral composition and hydration on solute transport in the rabbit sclera. Intermuscular sclera was excised from adult New Zealand rabbits. Tissue samples were either examined directly (controls), digested using chondroitinase ABC or crossli...

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Authors: Boubriak, O; Urban, J; Akhtar, S; Meek, K; Bron, A

• Publication status: Published
• Journal: Experimental eye research
• Volume: 71
• Issue: 5
• Pages: 503-514
• Publication date: 2000-11-01
• DOI: 10.1006/exer.2000.0909
• EISSN: 1096-0007
• ISSN: 0014-4835
• Language: English
• Keywords: Glycosaminoglycans; Molecular Weight; Glutaral; Sclera; Diffusion; Rabbits; Animals; Extracellular Matrix; Cross-Linking Reagents; Water-Electrolyte Balance; Solutions