Bromodomains, protein modules that recognize and bind to acetylated lysine, are emerging as important components of cellular machinery. These acetyl-lysine (KAc) "reader" domains are part of the write-read-erase concept that has been linked with the transfer of epigenetic information. By reading KAc marks on histones, bromodomains mediate protein-protein interactions between a diverse array of partners. There has been intense activity in developing potent and selective small molecule probes t...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
If you are the owner of this record, you can report an update to it here: Report update to this record