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Journal article

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.

Abstract:

Bromodomains, protein modules that recognize and bind to acetylated lysine, are emerging as important components of cellular machinery. These acetyl-lysine (KAc) "reader" domains are part of the write-read-erase concept that has been linked with the transfer of epigenetic information. By reading KAc marks on histones, bromodomains mediate protein-protein interactions between a diverse array of partners. There has been intense activity in developing potent and selective small molecule probes t...

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Publication status:
Published

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Publisher copy:
10.1021/jm300915b

Authors


Hewings, DS More by this author
Rooney, TP More by this author
Jennings, LE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Journal of medicinal chemistry
Volume:
55
Issue:
22
Pages:
9393-9413
Publication date:
2012-11-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:7f054681-270a-4838-b674-c656370fa6cf
Source identifiers:
352550
Local pid:
pubs:352550

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