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Interfacing membrane mimetics with mass spectrometry

Abstract:

Membrane proteins play critical physiological roles and make up the majority of drug targets. Due to their generally low expression levels and amphipathic nature, membrane proteins represent challenging molecular entities for biophysical study. Mass spectrometry offers several sensitive approaches to study the biophysics of membrane proteins. By preserving noncovalent interactions in the gas phase and using collisional activation to remove solubilization agents inside the mass spectrometer, n...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.accounts.6b00379

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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Funding agency for:
Robinson, CV
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Funding agency for:
Robinson, CV
Publisher:
American Chemical Society Publisher's website
Journal:
Accounts of Chemical Research Journal website
Volume:
49
Issue:
11
Pages:
2459–2467
Publication date:
2016-10-13
Acceptance date:
2016-10-03
DOI:
EISSN:
1520-4898
ISSN:
0001-4842
Pubs id:
pubs:653223
URN:
uri:7eda8c97-cb63-4dd2-9e47-a021d18330e2
UUID:
uuid:7eda8c97-cb63-4dd2-9e47-a021d18330e2
Local pid:
pubs:653223
Language:
English

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