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1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line.

Abstract:

Inducible synthesis of nitric oxide (NO) by macrophages is an important mechanism of the host defense against intracellular infection in mice, but the evidence for significant levels of inducible NO production by human macrophages is controversial. Here we report that the human promyelocytic cell line HL-60, when differentiated to a macrophage-like phenotype, acquires the ability to produce substantial amounts of NO on stimulation with LPS or 1, 25-dihydroxyvitamin D3 (1,25-D3) in the absence...

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Publication status:
Published

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Authors


Rockett, KA More by this author
Brookes, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
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Journal:
Infection and immunity
Volume:
66
Issue:
11
Pages:
5314-5321
Publication date:
1998-11-05
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:7ec6673b-ccef-4360-8403-cee1fad3b74d
Source identifiers:
36242
Local pid:
pubs:36242

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