Journal article icon

Journal article

GABA and muscimol inhibit the release of prolactin from dispersed rat anterior pituitary cells.

Abstract:
Prolactin release from columns of dispersed rat anterior pituitary cells was inhibited by GABA and the GABA agonist muscimol. The log dose-response curves for GABA and muscimol appeared to be parallel, but were not parallel to that for dopamine. Two GABA antagonists, bicuculline and picrotoxin, blocked the action of both GABA and muscimol, but the dopamine antagonists metoclopramide and perphenazine did not. The data suggest that there are specific GABA receptors on pituitary lactotrophs.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1159/000123147

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Delitala, G More by this author
Besser, GM More by this author
Journal:
Neuroendocrinology
Volume:
32
Issue:
3
Pages:
145-149
Publication date:
1981-03-05
DOI:
EISSN:
1423-0194
ISSN:
0028-3835
URN:
uuid:7ec07862-cff1-495a-a63a-2005af962ae2
Source identifiers:
138757
Local pid:
pubs:138757

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP