Journal article
Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells
- Abstract:
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Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the innate and adaptive immune systems. Some studies have reported that NK cell activation and cytokine secretion are controlled epigenetically, but have yielded only limited insight into the mechanisms. Using chemical screening with small-molecul...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 4.0MB)
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- Publisher copy:
- 10.1074/jbc.RA117.000698
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Authors
Funding
Kennedy Trust for Rheumatology Research
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National Institute for Health Research
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Cancer Research UK
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Publication date:
- 2018-01-04
- Acceptance date:
- 2018-01-04
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Source identifiers:
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819983
Item Description
- Pubs id:
-
pubs:819983
- UUID:
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uuid:7ea86411-7827-463d-a70a-74fafc24448c
- Local pid:
- pubs:819983
- Deposit date:
- 2018-01-16
Terms of use
- Copyright holder:
- © Cribbs, et al
- Copyright date:
- 2018
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from American Society for Biochemistry and Molecular Biology at: 10.1074/jbc.RA117.000698
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