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Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells

Abstract:

Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the innate and adaptive immune systems. Some studies have reported that NK cell activation and cytokine secretion are controlled epigenetically, but have yielded only limited insight into the mechanisms. Using chemical screening with small-molecul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1074/jbc.RA117.000698

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Hookway, E More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Publication date:
2018-01-04
Acceptance date:
2018-01-04
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:819983
URN:
uri:7ea86411-7827-463d-a70a-74fafc24448c
UUID:
uuid:7ea86411-7827-463d-a70a-74fafc24448c
Local pid:
pubs:819983

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