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Molecular dynamics simulations of heterogeneous cell membranes in response to uniaxial membrane stretches at high loading rates

Abstract:

The chemobiomechanical signatures of diseased cells are often distinctively different from that of healthy cells. This mainly arises from cellular structural/compositional alterations induced by disease development or therapeutic molecules. Therapeutic shock waves have the potential to mechanically destroy diseased cells and/or increase cell membrane permeability for drug delivery. However, the biomolecular mechanisms by which shock waves interact with diseased and healthy cellular components...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-06827-3

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Department:
Oxford, MPLS, Engineering Science
Cleveland, R More by this author
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US Army Research Laboratory More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
8316
Publication date:
2017-08-05
Acceptance date:
2017-06-19
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pubs id:
pubs:710085
URN:
uri:7e9ffbf0-afd4-4fcf-8aba-806f8b74d4e4
UUID:
uuid:7e9ffbf0-afd4-4fcf-8aba-806f8b74d4e4
Local pid:
pubs:710085
Keywords:

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