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Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines

Abstract:

Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to antigenic differences is very limited, yet cr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12916-014-0183-5

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Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
12
Publication date:
2014-10-16
Acceptance date:
2014-09-10
DOI:
EISSN:
1741-7015
Source identifiers:
500300
Keywords:
Pubs id:
pubs:500300
UUID:
uuid:7e94291a-c3f1-4227-9734-8c33d61a5ab3
Local pid:
pubs:500300
Deposit date:
2015-01-07

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