Journal article
Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines
- Abstract:
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Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to antigenic differences is very limited, yet cr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.1186/s12916-014-0183-5
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Medicine Journal website
- Volume:
- 12
- Publication date:
- 2014-10-16
- Acceptance date:
- 2014-09-10
- DOI:
- EISSN:
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1741-7015
- Source identifiers:
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500300
Item Description
- Keywords:
- Pubs id:
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pubs:500300
- UUID:
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uuid:7e94291a-c3f1-4227-9734-8c33d61a5ab3
- Local pid:
- pubs:500300
- Deposit date:
- 2015-01-07
Terms of use
- Copyright holder:
- Terheggen et al
- Copyright date:
- 2014
- Notes:
- © 2014 Terheggen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Licence:
- CC Attribution (CC BY)
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