A prominent feature of many human cancers is oncogene-driven activation of the DNA damage response (DDR) during early tumorigenesis. It has been shown previously that noninvasive imaging of the phosphorylated histone H2A variant H2AX, γH2AX, a DNA damage signaling protein, is possible using (111)In-labeled anti-γH2AX antibody conjugated to the cell-penetrating peptide transactivator of transcription (TAT). The purpose of this study was to investigate whether (111)In-anti-γH2AX-TAT detects the...Expand abstract
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- Peer reviewed
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- Society of Nuclear Medicine Publisher's website
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
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- Society of Nuclear Medicine and Molecular Imaging, Inc.
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Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.
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