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Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.

Abstract:

A prominent feature of many human cancers is oncogene-driven activation of the DNA damage response (DDR) during early tumorigenesis. It has been shown previously that noninvasive imaging of the phosphorylated histone H2A variant H2AX, γH2AX, a DNA damage signaling protein, is possible using (111)In-labeled anti-γH2AX antibody conjugated to the cell-penetrating peptide transactivator of transcription (TAT). The purpose of this study was to investigate whether (111)In-anti-γH2AX-TAT detects the...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2967/jnumed.114.142083

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Medical Research Council More from this funder
Cancer Research UK More from this funder
CR-UK/EPSRC Cancer Imaging Centre More from this funder
Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
Volume:
55
Issue:
12
Pages:
2026-2031
Publication date:
2014-12-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:7e8e9607-5928-454d-b3eb-fbcdd10a2085
Source identifiers:
492026
Local pid:
pubs:492026

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