- Abstract:
-
A prominent feature of many human cancers is oncogene-driven activation of the DNA damage response (DDR) during early tumorigenesis. It has been shown previously that noninvasive imaging of the phosphorylated histone H2A variant H2AX, γH2AX, a DNA damage signaling protein, is possible using (111)In-labeled anti-γH2AX antibody conjugated to the cell-penetrating peptide transactivator of transcription (TAT). The purpose of this study was to investigate whether (111)In-anti-γH2AX-TAT detects the...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.2967/jnumed.114.142083
-
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- Publisher:
- Society of Nuclear Medicine Publisher's website
- Journal:
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
- Volume:
- 55
- Issue:
- 12
- Pages:
- 2026-2031
- Publication date:
- 2014-12-05
- DOI:
- EISSN:
-
1535-5667
- ISSN:
-
0161-5505
- URN:
-
uuid:7e8e9607-5928-454d-b3eb-fbcdd10a2085
- Source identifiers:
-
492026
- Local pid:
- pubs:492026
- Language:
- English
- Keywords:
- Copyright holder:
- Society of Nuclear Medicine and Molecular Imaging, Inc.
- Copyright date:
- 2014
Journal article
Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.
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Medical Research Council
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Cancer Research UK
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CR-UK/EPSRC Cancer Imaging Centre
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