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Phenotypic characterization of HIV-specific CD8+ T cells during early and chronic infant HIV-1 infection.

Abstract:

Although CD8(+) T cells play an important role in the containment of adult HIV-1 replication, their role in infant HIV-1 infection is not as well understood. Impaired HIV-specific CD8(+) T cell responses may underlie the persistently high viral loads observed in infants. We examined the frequency and phenotype of infant HIV-specific CD8(+) T cells in 7 HIV-infected antiretroviral therapy-naive infants during the first 2 years of life, using class I HLA tetramers and IFN-(Gamma)-ELISPOT. The f...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0020375

Authors


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Institution:
University of Oxford
John-Stewart, GC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Lohman-Payne, B More by this author
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Funding agency for:
Rowland-Jones, SL
U. S. National Institutes of Child Health and Disease More from this funder
Medical Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
5
Pages:
e20375
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:7e6c312f-06f4-4a23-b0b0-435f8921e6be
Source identifiers:
151222
Local pid:
pubs:151222

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