Journal article
Phenotypic characterization of HIV-specific CD8+ T cells during early and chronic infant HIV-1 infection.
- Abstract:
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Although CD8(+) T cells play an important role in the containment of adult HIV-1 replication, their role in infant HIV-1 infection is not as well understood. Impaired HIV-specific CD8(+) T cell responses may underlie the persistently high viral loads observed in infants. We examined the frequency and phenotype of infant HIV-specific CD8(+) T cells in 7 HIV-infected antiretroviral therapy-naive infants during the first 2 years of life, using class I HLA tetramers and IFN-(Gamma)-ELISPOT. The f...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 453.7KB)
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- Publisher copy:
- 10.1371/journal.pone.0020375
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Authors
Funding
U. S. National Institutes of Child Health and Disease
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+ Elizabeth Glaser Pediatric AIDS Foundation
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Funding agency for:
Rowland-Jones, S
Medical Research Council
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 6
- Issue:
- 5
- Pages:
- e20375
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
151222
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:7e6c312f-06f4-4a23-b0b0-435f8921e6be
- Local pid:
- pubs:151222
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Slyker et al
- Copyright date:
- 2011
- Notes:
- Copyright 2011 Slyker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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