- Abstract:
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Although CD8(+) T cells play an important role in the containment of adult HIV-1 replication, their role in infant HIV-1 infection is not as well understood. Impaired HIV-specific CD8(+) T cell responses may underlie the persistently high viral loads observed in infants. We examined the frequency and phenotype of infant HIV-specific CD8(+) T cells in 7 HIV-infected antiretroviral therapy-naive infants during the first 2 years of life, using class I HLA tetramers and IFN-(Gamma)-ELISPOT. The f...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 453.7kb)
-
- Publisher copy:
- 10.1371/journal.pone.0020375
-
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- Funding agency for:
- Rowland-Jones, SL
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 6
- Issue:
- 5
- Pages:
- e20375
- Publication date:
- 2011
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:7e6c312f-06f4-4a23-b0b0-435f8921e6be
- Source identifiers:
-
151222
- Local pid:
- pubs:151222
- Copyright holder:
- Slyker et al.
- Copyright date:
- 2011
- Notes:
- Copyright 2011 Slyker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Phenotypic characterization of HIV-specific CD8+ T cells during early and chronic infant HIV-1 infection.
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+ Elizabeth Glaser Pediatric AIDS Foundation
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U. S. National Institutes of Child Health and Disease
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Medical Research Council
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