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Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.

Abstract:

RecQ helicases are important maintainers of genome integrity with distinct roles in almost every cellular process requiring access to DNA. RECQL5 is one of five human RecQ proteins and is particularly versatile in this regard, forming protein complexes with a diverse set of cellular partners in order to coordinate its helicase activity to various processes including replication, recombination and DNA repair. In this study, we have determined crystal structures of the core helicase domain of R...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw1362

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Department:
Oxford, MSD, NDM, Structural Genomics Consortium
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Department:
Oxford, MSD, NDM, Structural Genomics Consortium
More by this author
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
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Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Bayer Pharma AG More from this funder
Boehringer Ingelheim More from this funder
Canada Foundation for Innovation More from this funder
Eshelman Institute for Innovation More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Publication date:
2017-01-18
Acceptance date:
2017-01-03
DOI:
ISSN:
1362-4962
Pubs id:
pubs:673440
URN:
uri:7e66eca9-905c-4072-8cf0-731f83b98962
UUID:
uuid:7e66eca9-905c-4072-8cf0-731f83b98962
Local pid:
pubs:673440
Language:
English
Keywords:

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