- Abstract:
-
1. Chloroquine diphosphate (15 mg base kg-1) was given by constant rate intravenous infusion to two groups of Thai subjects. Eleven were patients with malaria (10 with Plasmodium vivax and one case with Plasmodium malariae) and 10 were healthy normal volunteers. 2. Plasma and packed red-cell concentrations of chloroquine, electrocardiographic intervals, arterial blood pressure and pulse were measured at frequent intervals. 3. Peak plasma concentrations at the end of the infusion ranged from 9...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1988.tb03332.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 25
- Issue:
- 4
- Pages:
- 477-485
- Publication date:
- 1988-04-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:7e51fcb6-7431-4fe7-a268-f8166a5432d8
- Source identifiers:
-
19076
- Local pid:
- pubs:19076
- Language:
- English
- Keywords:
- Copyright date:
- 1988
Journal article
Pharmacokinetics of chloroquine in Thais: plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria.
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