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Pharmacokinetics of chloroquine in Thais: plasma and red-cell concentrations following an intravenous infusion to healthy subjects and patients with Plasmodium vivax malaria.

Abstract:

1. Chloroquine diphosphate (15 mg base kg-1) was given by constant rate intravenous infusion to two groups of Thai subjects. Eleven were patients with malaria (10 with Plasmodium vivax and one case with Plasmodium malariae) and 10 were healthy normal volunteers. 2. Plasma and packed red-cell concentrations of chloroquine, electrocardiographic intervals, arterial blood pressure and pulse were measured at frequent intervals. 3. Peak plasma concentrations at the end of the infusion ranged from 9...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
25
Issue:
4
Pages:
477-485
Publication date:
1988-04-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:7e51fcb6-7431-4fe7-a268-f8166a5432d8
Source identifiers:
19076
Local pid:
pubs:19076

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