Journal article icon

Journal article

Production of low-avidity antibody by infants after infection with serogroup B meningococci.

Abstract:
Experimental serogroup B meningococcal vaccines have induced only poor immune responses and have had little protective efficacy in children younger than 1 year of age. We used ELISA with potassium thiocyanate to compare the average avidity of antibody produced by infants with that of children older than 10 years after systemic disease. Infants produced specific antibody of lower average avidity than older children--a finding that correlates with absence of serum bactericidal activity in the serum samples of the same infants.
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics, Biomedical Research Centre
Journal:
Lancet
Volume:
356
Issue:
9247
Pages:
2065-2066
Publication date:
2000-12-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:7e36bb2f-c76f-4abc-aceb-f55f82aa3b8a
Source identifiers:
122237
Local pid:
pubs:122237

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP