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Journal article

Biomarkers for predicting clinical responses to HDAC inhibitors.

Abstract:

Post-translational modifications of histone and non-histone proteins by acetylation are known to play a key role in tumourigenesis. Pharmacological manipulation of acetylation has been possible with the identification of small molecule inhibitors of histone deacetylases (HDAC), the enzymes responsible for deacetylating lysine residues. An explosion of drug discovery efforts in recent years has led to the development of an extensive group of HDAC inhibitors, many of which have been shown pre-c...

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Publication status:
Published

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Authors


Stimson, L More by this author
La Thangue, NB More by this author
Journal:
Cancer letters
Volume:
280
Issue:
2
Pages:
177-183
Publication date:
2009-08-05
DOI:
EISSN:
1872-7980
ISSN:
0304-3835
URN:
uuid:7e226ebb-c191-4b93-91e7-c8fba1858d56
Source identifiers:
267110
Local pid:
pubs:267110

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