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Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.

Abstract:

Triglycerides in the beta-cell may be important for stimulus-secretion coupling, through provision of a lipid-derived signal, and for pathogenetic events in NIDDM, where lipids may adversely affect beta-cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in triglyceride hydrolysis. Here, we investigated whether this enzyme is also expressed and active in beta-cells. Northern blot analysis and reverse transcription-polymerase chain reaction demonstrated that HSL ...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.48.1.228

Authors


Svensson, H More by this author
Degerman, E More by this author
Sundler, F More by this author
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Journal:
Diabetes
Volume:
48
Issue:
1
Pages:
228-232
Publication date:
1999-01-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:7e201672-e145-4c7f-9388-65161a76bdea
Source identifiers:
14439
Local pid:
pubs:14439

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