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Journal article

Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation.

Abstract:

Here we demonstrate that type I protein kinase A is redoxactive, forming an interprotein disulfide bond between its two regulatory RI subunits in response to cellular hydrogen peroxide. This oxidative disulfide formation causes a subcellular translocation and activation of the kinase, resulting in phosphorylation of established substrate proteins. The translocation is mediated at least in part by the oxidized form of the kinase having an enhanced affinity for alpha-myosin heavy chain, which s...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m603952200

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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
31
Pages:
21827-21836
Publication date:
2006-08-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:7e1666b0-c423-4a69-b2d8-1a3a779a3ca3
Source identifiers:
230521
Local pid:
pubs:230521

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