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Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease?

Abstract:

There is growing evidence for exaggerated oscillatory neuronal synchronisation in patients with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called beta frequency band, relate to the cardinal symptoms of bradykinesia and rigidity. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can significantly improve these motor impairments. Recent evidence has demonstrated reduction of beta oscillations concurrent with alleviation of PD motor symptoms, rai...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fnint.2012.00047

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Molecular Medicine
Role:
Author
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Integrative Neuroscience Journal website
Volume:
6
Issue:
July 2012
Pages:
47
Publication date:
2012-07-10
Acceptance date:
2012-06-25
DOI:
EISSN:
1662-5145
ISSN:
1662-5145
URN:
uuid:7e07d259-f69b-43c1-9492-94b9326500c6
Source identifiers:
342481
Local pid:
pubs:342481
Language:
English
Keywords:

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