Journal article

Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease?

Abstract:: There is growing evidence for exaggerated oscillatory neuronal synchronisation in patients with Parkinson's disease (PD). In particular, oscillations at around 20 Hz, in the so-called beta frequency band, relate to the cardinal symptoms of bradykinesia and rigidity. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can significantly improve these motor impairments. Recent evidence has demonstrated reduction of beta oscillations concurrent with alleviation of PD motor symptoms, raising the possibility that suppression of aberrant activity may mediate the effects of DBS. Here we review the evidence supporting suppression of pathological oscillations during stimulation and discuss how this might underlie the efficacy of DBS. We also consider how beta activity may provide a feedback signal suitable for next generation closed-loop and intelligent stimulators.

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Eusebio, A., Cagnan, H., & Brown, P. (2012). Does suppression of oscillatory synchronisation mediate some of the therapeutic effects of DBS in patients with Parkinson's disease? Frontiers in Integrative Neuroscience, 6(July 2012), 47.

MLA Style

Eusebio, A., et al. “Does Suppression of Oscillatory Synchronisation Mediate Some of the Therapeutic Effects of DBS in Patients with Parkinson's Disease?” Frontiers in Integrative Neuroscience, vol. 6, no. July 2012, Frontiers Media, 2012, p. 47.

Chicago Style

Eusebio, A, H Cagnan, and P Brown. 2012. “Does Suppression of Oscillatory Synchronisation Mediate Some of the Therapeutic Effects of DBS in Patients with Parkinson's Disease?” Frontiers in Integrative Neuroscience 6 (July 2012): 47.
Share
Print

Access Document

Files:: fnint-06-00047.pdf

(Preview, Version of record, pdf, 575.8KB, Terms of use)

Publisher copy:: 10.3389/fnint.2012.00047

Authors

+ Eusebio, A More by this author

Role:: Author

+ Cagnan, H More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Weatherall Insti. of Molecular Medicine
Role:: Author

+ Brown, P More by this author

Role:: Author

Publisher:: Frontiers Media
Journal:: Frontiers in Integrative Neuroscience More from this journal
Volume:: 6
Issue:: July 2012
Pages:: 47
Publication date:: 2012-07-10
Acceptance date:: 2012-06-25
DOI:: 10.3389/fnint.2012.00047
EISSN:: 1662-5145
ISSN:: 1662-5145

Language:: English
Keywords:: SBTMR
UUID:: uuid:7e07d259-f69b-43c1-9492-94b9326500c6
Local pid:: pubs:342481
Source identifiers:: 342481
Deposit date:: 2014-06-24

Terms of use

Copyright holder:: Eusebio, et al
Copyright date:: 2012
Notes:: Copyright © 2012 Eusebio, Cagnan and Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

Licence:: CC Attribution (CC BY)

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP