Caffeine as an analgesic adjuvant for acute pain in adults.
BACKGROUND: Caffeine has been added to common analgesics such as paracetamol, ibuprofen, and aspirin, in the belief that it enhances analgesic efficacy. Evidence to support this belief is limited and often based on invalid comparisons. OBJECTIVES: To assess the relative efficacy in acute pain of a single dose of any analgesic plus caffeine against the same dose of analgesic alone. SEARCH METHODS: We searched CENTRAL, MEDLINE, EMBASE, and the Oxford Pain Relief Database to January 2012, and a...Expand abstract
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