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Journal article

Age and strain related aberrant Ca(2+) release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy

Abstract:

Patients with hypertrophic cardiomyopathy (HCM), particularly young adults, can die from arrhythmia but the mechanism underlying abnormal rhythm formation remains unknown. C57Bl6 x CBA/Ca mice carrying a cardiac actin (ACTC) E99K (Glu99Lys) mutation reproduce many aspects of human HCM including increased myofilament Ca(2+) sensitivity and sudden death in a proportion (up to 40%) of young (28-40 day old) animals. We studied the hearts of transgenic (TG - ACTC E99K) mice and their non-transgeni...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1152/ajpheart.00244.2017

Authors


Rowlands, C More by this author
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Publisher:
American Physiological Society Publisher's website
Journal:
AJP - Heart and Circulatory Physiology Journal website
Volume:
313
Issue:
6
Pages:
H1213-H1226
Publication date:
2017-12-11
Acceptance date:
2017-08-30
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Pubs id:
pubs:729322
URN:
uri:7df5d34a-c448-4b91-9442-f109db767609
UUID:
uuid:7df5d34a-c448-4b91-9442-f109db767609
Local pid:
pubs:729322

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