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Mitochondrial shape and function in trypanosomes requires the outer membrane protein, TbLOK1.

Abstract:

In an RNAi library screen for loss of kinetoplast DNA (kDNA), we identified an uncharacterized Trypanosoma brucei protein, named TbLOK1, required for maintenance of mitochondrial shape and function. We found the TbLOK1 protein located in discrete patches in the mitochondrial outer membrane. Knock-down of TbLOK1 in procyclic trypanosomes caused the highly interconnected mitochondrial structure to collapse, forming an unbranched tubule remarkably similar to the streamlined organelle seen in the...

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Publication status:
Published

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Publisher copy:
10.1111/mmi.12089

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Molecular microbiology
Volume:
87
Issue:
4
Pages:
713-729
Publication date:
2013-02-05
DOI:
EISSN:
1365-2958
ISSN:
0950-382X
URN:
uuid:7de98e99-235b-4430-ba0b-61b38f5477cd
Source identifiers:
375671
Local pid:
pubs:375671

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