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Determination of mosquito bloodmeal pH in situ by ion-selective microelectrode measurement: implications for the regulation of malarial gametogenesis.

Abstract:

Malarial gametocytes circulate in the peripheral blood of the vertebrate host as developmentally arrested intra-erythrocytic cells, which only resume development into gametes when ingested into the bloodmeal of the female mosquito vector. The ensuing development encompasses sexual reproduction and mediates parasite transmission to the insect. In vitro the induction of gametogenesis requires a drop in temperature and either a pH increase from physiological blood pH (ca pH 7.4) to about pH 8.0,...

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Publisher copy:
10.1017/s0031182099005946

Authors


Billker, O More by this author
Miller, AJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Parasitology
Volume:
120 ( Pt 6)
Issue:
6
Pages:
547-551
Publication date:
2000-06-05
DOI:
EISSN:
1469-8161
ISSN:
0031-1820
URN:
uuid:7ddabe2f-934e-4c4d-a31a-d37c8c4dc78a
Source identifiers:
266764
Local pid:
pubs:266764

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