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Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulation

Abstract:

Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and topologically-associating domains (TADs), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain obscure. Here we review physical principles driving proteins bound to long polymers into clusters surrounded by loops, and present a parsimonious y...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/nar/gky763

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Lincoln College; Lincoln College
ORCID:
0000-0002-6639-188X
Marenduzzo, D More by this author
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
46
Issue:
19
Pages:
9895–9906
Publication date:
2018-09-18
Acceptance date:
2018-09-14
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:921505
URN:
uri:7dd66897-8611-44d1-9cc2-19894c9dc4c9
UUID:
uuid:7dd66897-8611-44d1-9cc2-19894c9dc4c9
Local pid:
pubs:921505

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