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Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.

Abstract:

Rev is a key regulatory protein of human immunodeficiency virus type 1. Its function is to bind to viral transcripts and effect export from the nucleus of unspliced mRNA, thereby allowing the synthesis of structural proteins. Despite its evident importance, the structure of Rev has remained unknown, primarily because Rev's proclivity for polymerization and aggregation is an impediment to crystallization. Monoclonal antibody antigen-binding domains (Fabs) have proven useful for the co-crystall...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.01.061

Authors


DiMattia, MA More by this author
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Journal:
Journal of molecular biology
Volume:
397
Issue:
3
Pages:
697-708
Publication date:
2010-04-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:7dd19eac-5848-44e8-b3da-84680d203a09
Source identifiers:
53357
Local pid:
pubs:53357

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